Laboratory for Control, Learning, and Systems Biology

diffusion

2014
  1. Z. Aminzare, Y. Shafi, M. Arcak, E.D. Sontag, "Guaranteeing spatial uniformity in reaction-diffusion systems using weighted L_2-norm contractions", In A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations, pp. 73-101, 2014. pdf
    Abstract

    This paper gives conditions that guarantee spatial uniformity of the solutions of reaction-diffusion partial differential equations, stated in terms of the Jacobian matrix and Neumann eigenvalues of elliptic operators on the given spatial domain, and similar conditions for diffusively-coupled networks of ordinary differential equations. Also derived are numerical tests making use of linear matrix inequalities that are useful in certifying these conditions.

2013
  1. Z. Aminzare, E.D. Sontag, "Logarithmic Lipschitz norms and diffusion-induced instability", Nonlinear Analysis: Theory, Methods & Applications, vol. 83, pp. 31-49, 2013. pdf
    Abstract

    This paper proves that ordinary differential equation systems that are contractive with respect to L^p norms remain so when diffusion is added. Thus, diffusive instabilities, in the sense of the Turing phenomenon, cannot arise for such systems, and in fact any two solutions converge exponentially to each other. The key tools are semi-inner products and logarithmic Lipschitz constants in Banach spaces. An example from biochemistry is discussed, which shows the necessity of considering non-Hilbert spaces. An analogous result for graph-defined interconnections of systems defined by ordinary differential equations is given as well.

  2. Y. Shafi, Z. Aminzare, M. Arcak, E.D. Sontag, "Spatial uniformity in diffusively-coupled systems using weighted L2 norm contractions", In Proc. American Control Conference, pp. 5639-5644, 2013. pdf
    Abstract

    We present conditions that guarantee spatial uniformity in diffusively-coupled systems. Diffusive coupling is a ubiquitous form of local interaction, arising in diverse areas including multiagent coordination and pattern formation in biochemical networks. The conditions we derive make use of the Jacobian matrix and Neumann eigenvalues of elliptic operators, and generalize and unify existing theory about asymptotic convergence of trajectories of reaction-diffusion partial differential equations as well as compartmental ordinary differential equations. We present numerical tests making use of linear matrix inequalities that may be used to certify these conditions. We discuss an example pertaining to electromechanical oscillators. The paper's main contributions are unified verifiable relaxed conditions that guarantee synchrony.

2008
  1. M.R. Jovanovi\'c, M. Arcak, E.D. Sontag, "A passivity-based approach to stability of spatially distributed systems with a cyclic interconnection structure", IEEE Transactions on Circuits and Systems, Special Issue on Systems Biology, vol. 55, pp. 75-86, 2008. pdf
    Preprint: also arXiv math.OC/0701622, 22 January 2007.
    Abstract

    A class of distributed systems with a cyclic interconnection structure is considered. These systems arise in several biochemical applications and they can undergo diffusion driven instability which leads to a formation of spatially heterogeneous patterns. In this paper, a class of cyclic systems in which addition of diffusion does not have a destabilizing effect is identified. For these systems global stability results hold if the "secant" criterion is satisfied. In the linear case, it is shown that the secant condition is necessary and sufficient for the existence of a decoupled quadratic Lyapunov function, which extends a recent diagonal stability result to partial differential equations. For reaction-diffusion equations with nondecreasing coupling nonlinearities global asymptotic stability of the origin is established. All of the derived results remain true for both linear and nonlinear positive diffusion terms. Similar results are shown for compartmental systems.