delay-differential systems

In this note, we show how certain properties of Goldbeter's 1995 model for circadian oscillations can be proved mathematically, using techniques from the recently developed theory of monotone systems with inputs and outputs. The theory establishes global asymptotic stability, and in particular no oscillations, if the rate of transcription is somewhat smaller than that assumed by Goldbeter, based on the application of a tight small gain condition. This stability persists even under arbitrary delays in the feedback loop. On the other hand, when the condition is violated a Poincare'-Bendixson result allows to conclude existence of oscillations, for sufficiently high delays.

This paper further develops a method, originally introduced in a paper by Angeli and Sontag, for proving global attractivity of steady states in certain classes of dynamical systems. In this aproach, one views the given system as a negative feedback loop of a monotone controlled system. An auxiliary discrete system, whose global attractivity implies that of the original system, plays a key role in the theory, which is presented in a general Banach space setting. Applications are given to delay systems, as well as to systems with multiple inputs and outputs, and the question of expressing a given system in the required negative feedback form is addressed.

We show how certain properties of Goldbeter's original 1995 model for circadian oscillations can be proved mathematically. We establish global asymptotic stability, and in particular no oscillations, if the rate of transcription is somewhat smaller than that assumed by Goldbeter, but, on the other hand, this stability persists even under arbitrary delays in the feedback loop. We are mainly interested in illustrating certain mathematical techniques, including the use of theorems concerning tridiagonal cooperative systems and the recently developed theory of monotone systems with inputs and outputs.

We prove the global asymptotic stability of a well-known delayed negative-feedback model of testosterone dynamics, which has been proposed as a model of oscillatory behavior. We establish stability (and hence the impossibility of oscillations) even in the presence of delays of arbitrary length.

This note establishes a result linking algebraically coprime factorizations of transfer matrices of delay systems to approximately coprime factorizations in the sense of distributions. The latter have been employed by the second author in the study of function-space controllability for such systems.

This paper studies the problem of obtaining minimal realizations of linear input/output maps defined over rings. In particular, it is shown that, contrary to the case of systems over fields, it is in general impossible to obtain realizations whose dimiension equals the rank of the Hankel matrix. A characterization is given of those (Noetherian) rings over which realizations of such dimensions can he always obtained, and the result is applied to delay-differential systems.

An abstract operator approach is introduced, permitting a unified study of discrete- and continuous-time linear control systems. As an application, an algorithm is given for deciding if a linear system can be built from any fixed set of linear components. Finally, a criterion is given for reachability of the abstract systems introduced, giving thus a unified proof of known reachability results for discrete-time, continuous-time, and delay-differential systems.

This paper deals with observability properties of realizations of linear response maps defined over commutative rings. A characterization is given for those maps which admit realizations which are simultaneously reachable and observable in a strong sense. Applications are given to delay-differential systems.