Laboratory for Control, Learning, and Systems Biology

observers

2014
  1. M. Skataric, E.D. Sontag, "Remarks on model-based estimation of nonhomogeneous Poisson processes and applications to biological systems", In Proc. European Control Conference, Strasbourg, France, June 2014, pp. 2052-2057, 2014. pdf
    Abstract

    This paper studies model-based estimation methods of a rate of a nonhomogeneous Poisson processes that describes events arising from modeling biological phenomena in which discrete events are measured. We describe an approach based on observers and Kalman filters as well as preliminary simulation results, and compare these to other methods (not model-based) in the literature. The problem is motivated by the question of identification of internal states from neural spikes and bacterial tumbling behavior.

2002
  1. M. Chaves, E.D. Sontag, "State-Estimators for chemical reaction networks of Feinberg-Horn-Jackson zero deficiency type", European J.\ Control, vol. 8, pp. 343–359, 2002. pdf
    Abstract

    This paper provides a necessary and sufficient condition for detectability, and an explicit construction of observers when this condition is satisfied, for chemical reaction networks of the Feinberg-Horn-Jackson zero deficiency type.

2001
  1. M. Chaves, E.D. Sontag, "Observers for certain chemical reaction networks", In Proc.\ 2001 European Control Conf., Sep.\ 2001, pp. 3715–3720, 2001.
1997
  1. E.D. Sontag, Y. Wang, "Output-to-state stability and detectability of nonlinear systems", Systems Control Lett., vol. 29, no. 5, pp. 279–290, 1997. doipdf
    Abstract

    The notion of input-to-state stability (ISS) has proved to be useful in nonlinear systems analysis. This paper discusses a dual notion, output-to-state stability (OSS). A characterization is provided in terms of a dissipation inequality involving storage (Lyapunov) functions. Combining ISS and OSS there results the notion of input/output-to-state stability (IOSS), which is also studied and related to the notion of detectability, the existence of observers, and output injection.

1980
  1. M. L. J. Hautus, E.D. Sontag, "An approach to detectability and observers", In Algebraic and geometric methods in linear systems theory (AMS-NASA-NATO Summer Sem., Harvard Univ., Cambridge, Mass., 1979), pp. 99–135, 1980. pdf
    Abstract

    This paper proposes an approach to the problem of establishing the existence of observers for deterministic dynamical systems. This approach differs from the standard one based on Luenberger observers in that the observation error is not required to be Markovian given the past input and output data. A general abstract result is given, which special- izes to new results for parametrized families of linear systems, delay systems and other classes of systems. Related problems of feedback control and regulation are also studied.