Laboratory for Control, Learning, and Systems Biology

Papers by A.C.B de Oliveira and E.D. Sontag

2026
  1. A.C.B de Oliveira, M.K. Wafi, Eduardo D. Sontag, "On input-output persistency and the interconnection of positive nonlinear systems", arXiv, pp. 2608.01699, 2026. www
    Abstract

    In this paper we study feedback interconnections of positive nonlinear SISO systems and introduce two complementary properties: persistent-input/persistent-output (PIPO) for the plant and persistent-input/transient-output (PITO) for the controller. Assuming forward completeness of the closed loop and a one-sided affine growth bound on the controller output, we show that PIPO and PITO jointly imply boundedness of the control signal. The result is input-output in nature and does not require linearity or monotonicity of the interconnected subsystems, although it does not in general guarantee boundedness of the full controller state. We provide a structural PIPO condition for positive monotone plants with a class-K_infinity steady-state characteristic, establish PITO for the antithetic integral controller with explicit gains, and illustrate the framework on a nonlinear integral-feedback motif with multiplicative controller growth.

  2. M.K. Wafi, A.C.B de Oliveira, E.D. Sontag, "Boundedness of solutions in feedback systems with antithetic controllers", 2026.
    Submitted. Preprint in arXiv 2604.27290.
    Abstract

    Antithetic feedback controllers have become a key experimental and theoretical tool in synthetic biology. Introduced by Khammash and collaborators about 10 years ago, they are employed in order to achieve the practical regulation of protein expression, including tracking and robust disturbance rejection. In closed-loop, there are unique equilibria which, depending on parameter values, can be unstable. It had been shown, however, that this instability is not arbitrary: any bounded trajectory that stays away from the equilibrium must converge to a periodic orbit. This motivated a long-standing open question: is every trajectory bounded? In other words, even if the equilibrium is unstable, can nonlinear effects prevent unbounded excursions in the state space? This paper provides an affirmative answer, establishing the boundedness of all solutions. Previous attempts to prove this fact using Lyapunov functions had no success. Instead, this paper takes a completely different approach, specific to antithetic configurations, in which the key idea is to think of the controller as providing a ``persistently negative feedback'' which acts far away from the equilibrium in such a way so as to keep trajectories from diverging. This new approach, although tailored to the antithetic controller, might be useful in other applications as well.

  3. M.K. Wafi, A.C.B de Oliveira, E.D. Sontag, "When is cumulative dose response monotonic? Analysis of incoherent feedforward motifs", In Proc. 65th IEEE Conference on Decision and Control (CDC), 2026.
    To appear. Also arXiv:2604.01573
    Abstract

    We study the monotonicity of the cumulative dose response (cDR) for a class of incoherent feedforward motif (IFFMs) systems with linear intermediate dynamics and nonlinear output dynamics. While the instantaneous dose response (DR) may be nonmonotone with respect to the input, the cDR can still be monotone. To analyze this phenomenon, we derive an integral representation of the sensitivity of cDR with respect to the input and establish general sufficient conditions for both monotonicity and non-monotonicity. These results reduce the problem to verifying qualitative sign properties along system trajectories. We apply this framework to four canonical IFFM systems and obtain a complete characterization of their behavior. In particular, IFFM1 and IFFM3 exhibit monotone cDR despite potentially non-monotone DR, while IFFM2 is monotone already at the level of DR, which implies monotonicity of cDR. In contrast, IFFM4 violates these conditions, leading to a loss of monotonicity. Numerical simulations indicate that these properties persist beyond the structured initial conditions used in the analysis. Overall, our results provide a unified framework for understanding how network structure governs monotonicity in cumulative input–output responses.

  4. M.K. Wafi, A.C.B de Oliveira, E.D. Sontag, "On the (almost) global exponential convergence of overparameterized policy optimization for the LQR problem", In 2026 American Control Conference (ACC), pp. 2819-2824, 2026. pdf
    To appear. See also 2025 arXiv:2510.02140
    Abstract

    In this work we study the convergence of gradient methods for nonconvex optimization problems – specifically the effect of the problem formulation to the convergence behavior of the solution of a gradient flow. We show through a simple example that, surprisingly, the gradient flow solution can be exponentially or asymptotically convergent, depending on how the problem is formulated. We then deepen the analysis and show that a policy optimization strategy for the continuous-time linear quadratic regulator (LQR) (which is known to present only asymptotic convergence globally) presents almost global exponential convergence if the problem is overparameterized through a linear feed-forward neural network (LFFNN). We prove this qualitative improvement always happens for a simplified version of the LQR problem and derive explicit convergence rates for the gradient flow. Finally, we show that both the qualitative improvement and the quantitative rate gains persist in the general LQR through numerical simulations.

2025
  1. A.C.B de Oliveira, L. Cui, E. D. Sontag, "Remarks on the Polyak-Lojasiewicz inequality and the convergence of gradient systems", In Proc. 64th IEEE Conference on Decision and Control (CDC), pp. 1150-1155, 2025. doipdf
    Extended version in arXiv:2503.23641
    Abstract

    This work explores generalizations of the Polyak-Lojasiewicz inequality (PLI) and their implications for the convergence behavior of gradient flows in optimization problems. Motivated by the continuous-time linear quadratic regulator (CT-LQR) policy optimization problem – where only a weaker version of the PLI is characterized in the literature – this work shows that while weaker conditions are sufficient for global convergence to, and optimality of the set of critical points of the cost function, the "profile" of the gradient flow solution can change significantly depending on which "flavor" of inequality the cost satisfies. After a general theoretical analysis, we focus on fitting the CT-LQR policy optimization problem to the proposed framework, showing that, in fact, it can never satisfy a PLI in its strongest form. We follow up our analysis with a brief discussion on the difference between continuous- and discrete-time LQR policy optimization, and end the paper with some intuition on the extension of this framework to optimization problems with L1 regularization and solved through proximal gradient flows.

  2. A.C.B de Oliveira, M. Siami, E.D. Sontag, "Convergence analysis of overparametrized LQR formulations", Automatica, vol. 182, pp. 112504, 2025. pdf
    Version with more details in arXiv 2408.15456
    Abstract

    Motivated by the growing use of Artificial Intelligence (AI) tools in control design, this paper takes the first steps towards bridging the gap between results from Direct Gradient methods for the Linear Quadratic Regulator (LQR), and neural networks. More specifically, it looks into the case where one wants to find a Linear Feed-Forward Neural Network (LFFNN) feedback that minimizes a LQR cost. This paper starts by computing the gradient formulas for the parameters of each layer, which are used to derive a key conservation law of the system. This conservation law is then leveraged to prove boundedness and global convergence of solutions to critical points, and invariance of the set of stabilizing networks under the training dynamics. This is followed by an analysis of the case where the LFFNN has a single hidden layer. For this case, the paper proves that the training converges not only to critical points but to the optimal feedback control law for all but a set of measure-zero of the initializations. These theoretical results are followed by an extensive analysis of a simple version of the problem (the ``vector case''), proving the theoretical properties of accelerated convergence and robustness for this simpler example. Finally, the paper presents numerical evidence of faster convergence of the training of general LFFNNs when compared to traditional direct gradient methods, showing that the acceleration of the solution is observable even when the gradient is not explicitly computed but estimated from evaluations of the cost function.

  3. A.C.B. de Oliveira, M. Siami, E. D. Sontag, "Regularising numerical extremals along singular arcs: a Lie-theoretic approach", In Geometry, Topology and Control System Design: Proceedings of a Banff International Research Station Workshop, pp. 75-89, 2025. pdf
    Abstract

    Numerical ``direct'' approaches to time-optimal control often fail to find solutions that are singular in the sense of the Pontryagin Maximum Principle. These approaches behave better when searching for saturated (bang-bang) solutions. In previous work by one of the authors, singular solutions were theoretically shown to exist for the time-optimal problem for two-link manipulators under hard torque constraints. The theoretical results gave explicit formulas, based on Lie theory, for singular segments of trajectories, but the global structure of solutions remains unknown. In this work, we show how to effectively combine these theoretically found formulas with the use of general-purpose optimal control softwares. By using the explicit formula given by theory in the intervals where the numerical solution enters a singular arcs, we not only obtain an algebraic expression for the control in that interval, but we are also able to remove artifacts present in the numerical solution. In this way, the best features of numerical algorithms and theory complement each other and provide a better picture of the global optimal structure. We showcase the technique on a 2 degrees of freedom robotic arm example, and also propose a way of extending the analyzed method to robotic arms with higher degrees of freedom through partial feedback linearization, assuming the desired task can be mostly performed by a few of the degrees of freedom of the robot and imposing some prespecified trajectory on the remaining joints.

2024
  1. A.C.B de Oliveira, M. Siami, E.D. Sontag, "Remarks on the gradient training of linear neural network based feedback for the LQR Problem", In Proc. 2024 63rd IEEE Conference on Decision and Control (CDC), pp. 7846-7852, 2024. pdf
    Abstract

    Motivated by the current interest in using Artificial intelligence (AI) tools in control design, this paper takes the first steps towards bridging results from gradient methods for solving the LQR control problem, and neural networks. More specifically, it looks into the case where one wants to find a Linear Feed-Forward Neural Network (LFFNN) that minimizes the Linear Quadratic Regulator (LQR) cost. This work develops gradient formulas that can be used to implement the training of LFFNNs to solve the LQR problem, and derives an important conservation law of the system. This conservation law is then leveraged to prove global convergence of solutions and invariance of the set of stabilizing networks under the training dynamics. These theoretical results are then followed by and extensive analysis of the simplest version of the problem (the ``scalar case'') and by numerical evidence of faster convergence of the training of general LFFNNs when compared to traditional direct gradient methods. These results not only serve as indication of the theoretical value of studying such a problem, but also of the practical value of LFFNNs as design tools for data-driven control applications.

  2. A.C.B. de Oliveira, M. Siami, E. D. Sontag, "Edge selections in bilinear dynamic networks", IEEE Transactions on Automatic Control, vol. 69, no. 1, pp. 331-338, 2024. doipdf
    Abstract

    We develop some basic principles for the design and robustness analysis of a continuous-time bilinear dynamical network, where an attacker can manipulate the strength of the interconnections/edges between some of the agents/nodes. We formulate the edge protection optimization problem of picking a limited number of attack-free edges and minimizing the impact of the attack over the bilinear dynamical network. In particular, the H2-norm of bilinear systems is known to capture robustness and performance properties analogous to its linear counterpart and provides valuable insights for identifying which edges are most sensitive to attacks. The exact optimization problem is combinatorial in the number of edges, and brute-force approaches show poor scalability. However, we show that the H2-norm as a cost function is supermodular and, therefore, allows for efficient greedy approximations of the optimal solution. We illustrate and compare the effectiveness of our theoretical findings via numerical simulation.

2023
  1. A.C.B de Oliveira, M. Siami, E.D. Sontag, "Dynamics and perturbations of overparameterized linear neural networks", In Proc. 2023 62st IEEE Conference on Decision and Control (CDC), pp. 7356-7361, 2023. doipdf
    Extended version is "On the ISS property of the gradient flow for single hidden-layer neural networks with linear activations", arXiv https://arxiv.org/abs/2305.09904
    Abstract

    Recent research in neural networks and machine learning suggests that using many more parameters than strictly required by the initial complexity of a regression problem can result in more accurate or faster-converging models – contrary to classical statistical belief. This phenomenon, sometimes known as ``benign overfitting'', raises questions regarding in what other ways might overparameterization affect the properties of a learning problem. In this work, we investigate the effects of overfitting on the robustness of gradient-descent training when subject to uncertainty on the gradient estimation. This uncertainty arises naturally if the gradient is estimated from noisy data or directly measured. Our object of study is a linear neural network with a single, arbitrarily wide, hidden layer and an arbitrary number of inputs and outputs. In this paper we solve the problem for the case where the input and output of our neural-network are one-dimensional, deriving sufficient conditions for robustness of our system based on necessary and sufficient conditions for convergence in the undisturbed case. We then show that the general overparametrized formulation introduces a set of spurious equilibria which lay outside the set where the loss function is minimized, and discuss directions of future work that might extend our current results for more general formulations.

2022
  1. A.C.B de Oliveira, M. Siami, E.D. Sontag, "Sensor and actuator scheduling in bilinear dynamical networks", In Proc. 2022 61st IEEE Conference on Decision and Control (CDC), pp. WeCT09.4, 2022. pdf
    Abstract

    In this paper, we investigate the problem of finding a sparse sensor and actuator (S/A) schedule that minimizes the approximation error between the input-output behavior of a fully sensed/actuated bilinear system and the system with the scheduling. The quality of this approximation is measuredby an H2-like metric, which is defined for a bilinear (time-varying) system with S/A scheduling based on the discrete Laplace transform of its Volterra kernels. First, we discuss the difficulties of designing S/A schedules for bilinear systems, which prevented us from finding a polynomial time algorithmfor solving the problem. We then propose a polynomial-time S/A scheduling heuristic that selects a fraction of sensors and node actuators at each time step while maintaining a small approximation error between the input-output behavior of thefully sensed/actuated system and the one with S/A scheduling in this H2-based sense. Numerical experiments illustrate the good approximation quality of our proposed methods.

2021
  1. A.C.B de Oliveira, M. Siami, E.D. Sontag, "Eminence in noisy bilinear networks", In Proc. 2021 60th IEEE Conference on Decision and Control (CDC), pp. 4835-4840, 2021. pdf
    Abstract

    When measuring importance of nodes in a network, the interconnections and dynamics are often supposed to be perfectly known. In this paper, we consider networks of agents with both uncertain couplings and dynamics. Network uncertainty is modeled by structured additive stochastic disturbances on each agent's update dynamics and coupling weights. We then study how these uncertainties change the network's centralities. Disturbances on the couplings between agents resul in bilinear dynamics, and classical centrality indices from linear network theory need to be redefined. To do that, we first show that, similarly to its linear counterpart, the squared H2 norm of bilinear systems measures the trace of the steady-state error covariance matrix subject to stochastic disturbances. This makes the H2 norm a natural candidate for a performance metric of the system. We propose a centrality index for the agents based on the H2 norm, and show how it depends on the network topology and the noise structure. Finally, we simulate a few graphs to illustrate how uncertainties on different couplings affect the agents' centrality rankings compared to a linearized model of the same system.

  2. A.C.B de Oliveira, M. Siami, E.D. Sontag, "Bilinear dynamical networks under malicious attack: an efficient edge protection method", In Proc. 2021 Automatic Control Conference, pp. 1210-1216, 2021. pdf
    Abstract

    In large-scale networks, agents and links are often vulnerable to attacks. This paper focuses on continuous-time bilinear networks, where additive disturbances model attacks or uncertainties on agents/states (node disturbances), and multiplicative disturbances model attacks or uncertainties on couplings between agents/states (link disturbances). It investigates network robustness notion in terms of the underlying digraph of the network, and structure of exogenous uncertainties and attacks. Specifically, it defines a robustness measure using the H_2-norm of the network and calculates it in terms of the reachability Gramian of the bilinear system. The main result is that under certain conditions, the measure is supermodular over the set of all possible attacked links. The supermodular property facilitates the efficient solution finding of the optimization problem. Examples illustrate how different structures can make the system more or less vulnerable to malicious attacks on links.