Laboratory for Control, Learning, and Systems Biology

epidemics

2021
  1. E. A. Hernandez-Vargas, G. Giordano, E.D. Sontag, J. G. Chase, H. Chang, A. Astolfi, "Second special section on systems and control research efforts against COVID-19 and future pandemics", Annual Reviews in Control, vol. 51, pp. 424-425, 2021. wwwdoi
  2. E. A. Hernandez-Vargas, G. Giordano, E.D. Sontag, J. G. Chase, H. Chang, A. Astolfi, "Third special section on systems and control research efforts against COVID-19 and future pandemics", Annual Reviews in Control, vol. 52, pp. 446-447, 2021. wwwdoi
  3. E.D. Sontag, "An explicit formula for minimizing the infected peak in an SIR epidemic model when using a fixed number of complete lockdowns", International Journal of Robust and Nonlinear Control, Special Issue on Control-Theoretic Approaches for Systems in the Life Sciences, pp. 1-24, 2021. pdf
    Abstract

    Careful timing of NPIs (non-pharmaceutical interventions) such as social distancing may avoid high ``second waves'' of infections of COVID-19. This paper asks what should be the timing of a set of K complete-lockdowns of prespecified lengths (such as two weeks) so as to minimize the peak of the infective compartment. Perhaps surprisingly, it is possible to give an explicit and easily computable rule for when each lockdown should commence. Simulations are used to show that the rule remains fairly accurate even if lockdowns are not perfect.

2020
  1. E. A. Hernandez-Vargas, G. Giordano, E.D. Sontag, J. G. Chase, H. Chang, A. Astolfi, "First special section on systems and control research efforts against COVID-19 and future pandemics", Annual Reviews in Control, vol. 50, pp. 343-344, 2020. wwwdoi