Laboratory for Control, Learning, and Systems Biology

Papers by A.J. Meyer and E.D. Sontag

2014
  1. ▪T.H. Segall-Shapiro, A.J. Meyer, A.D. Ellington, E.D. Sontag, C.A. Voigt, "A `resource allocator' for transcription based on a highly fragmented T7 RNA polymerase", Molecular Systems Biology, vol. 10, pp. 742-, 2014. wwwpdf
    systems biology · synthetic biology · gene expression
    Abstract

    A transcriptional system is built based on a 'resource allocator' that sets a core RNAP concentration, which is then shared by multiple sigma fragments, which provide specificity. Adjusting the concentration of the core sets the maximum transcriptional capacity available to a synthetic system.