Laboratory for Control, Learning, and Systems Biology

Papers by R.M. Levy and E.D. Sontag

2005
  1. ▪M. Andrec, B.N. Kholodenko, R.M. Levy, E.D. Sontag, "Inference of signaling and gene regulatory networks by steady-state perturbation experiments: structure and accuracy", J. Theoret. Biol., vol. 232, no. 3, pp. 427–441, 2005. pdf
    Supplementary materials are here: http://sontaglab.org/FTPDIR/andrec-kholodenko-levy-sontag-JTB04-supplementary.pdf
    modular response analysis · systems biology · reaction networks · reverse engineering · gene and protein networks · protein networks · gene networks · systems identification
    Abstract

    One of the fundamental problems of cell biology is the understanding of complex regulatory networks. Such networks are ubiquitous in cells, and knowledge of their properties is essential for the understanding of cellular behavior. This paper studies the effect of experimental uncertainty on the accuracy of the inferred structure of the networks determined using the method in "Untangling the wires: a novel strategy to trace functional interactions in signaling and gene networks".