2013
- ▪L. Liu, G. Duclos, B. Sun, J. Lee, A. Wu, Y. Kam, E.D. Sontag, H.A. Stone, J.C. Sturm, R.A. Gatenby, R.H. Austin, "Minimization of thermodynamic costs in cancer cell invasion", Proc Natl Acad Sci USA, vol. 110, pp. 1686-1691, 2013. pdf
Abstract
This paper shows that metastatic breast cancer cells cooperatively invade a 3D collagen matrix while following a glucose gradient. The front cell leadership is dynamic, and invading cells act in a cooperative manner by exchanging leaders in the invading front.