2008
- ▪T. Riley, E.D. Sontag, P. Chen, A. Levine, "The transcriptional regulation of human p53-regulated genes", Nature Reviews Molecular Cell Biology, vol. 9, pp. 402-412, 2008. pdf
Abstract
The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.