1. K. Wood, S. Nishida, E.D. Sontag, and P. Cluzel. Mechanism-independent method for predicting response to multiple drug exposure in bacteria. Proc Natl Acad Sci USA, 109:12254-12259, 2012. [PDF] Keyword(s): systems biology, drug interactions. Abstract:

   Drugs are commonly used in combinations larger than two for treating bacterial infections. It is generally impossible to infer directly from the effects of individual drugs the net effect of a multi-drug combination. This paper describes an empirically derived mechanism-independent method for predicting the microbial growth response to combinations of more than two drugs, experimentally tested on both gram-negative (Escherichia coli) and grampositive (Staphylococcus aureus) bacteria. The method shows that for a wide range of drugs, the bacterial responses to drug pairs are sufficient to infer the effects of larger drug combinations, and provides a simple formula for the prediction.

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