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Publications of Eduardo D. Sontag jointly with T. Lin
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Articles in journal or book chapters
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L. Yang,
E.M. Dolan,
S.K. Tan,
T. Lin,
E.D. Sontag,
and S.D. Khare.
Computation-guided design of a stimulus-responsive multi-enzyme supramolecular assembly, systems biology.
ChemBioChem,
18:2000-2006,
2017.
[PDF]
Abstract:
This paper reports on the construction of a phosphorylation- and optically-responsive supramolecular complex of metabolic pathway enzymes for the biodegradation of an environmental pollutant. Fusing of enzymes led to an increase in pathway efficiency, and illustrates the possibility of spatio-temporal control over formation and functioning of a wide variety of synthetic biotransformations. |
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